Celltheon SUPERCELL™ - CHO-K1 derived cell line developed through genetic engineering and directed evolution to enhance expression of difficult to express proteins, improve protein quality, and enhance metabolic function of the CHO cell.
CHO cells, although great for high expression and complex protein folding/glycosylation, are hampered by the generation of toxic metabolic byproducts. These byproducts make scale-up to larger production vessels time consuming and expensive. With average lead times before entering production routinely at >8 months, scaleup is a key sticking point in the drug development process. In an effort to remove major roadblocks in scaleup, CT SUPERCELLs™ have been engineered to reduce the toxic byproducts that hinder cell growth, viability, and expression at large scales. With ammonia and lactate at negligible levels, the benefits of SUPERCELL™ can be seen in protein quality, cell growth, and expression.
Key Features of Celltheon SUPERCELL™: